As rare disease trials face persistent feasibility challenges, Bayesian designs are gaining momentum by enabling more ...

Many engineering challenges come down to the same headache—too many knobs to turn and too few chances to test them. Whether tuning a power grid or designing a safer vehicle, each evaluation can be ...

The FDA has released draft guidance on how sponsors can use Bayesian models for clinical trials.

A new study introduces a global probabilistic forecasting model that predicts when and where ionospheric disturbances—measured by the Rate of total electron content (TEC) Index (ROTI)—are likely to ...

Marty Makary was appointed commissioner of the Food and Drug Administration (FDA) in 2025. The prominent surgeon, medical researcher, bestselling author, and critic of the medical ...

However, traditional clinical trial designs are often ill-suited for rare disease research with common challenges including ...

Phosphodiesterase 4 (PDE4) inhibition is associated with antiinflammatory and antifibrotic effects that may be beneficial in patients with idiopathic pulmonary fibrosis. In this phase 2, double-blind, ...

In recent years, something unexpected has been happening in artificial intelligence. Modern AI appears to be breaking a rule that statisticians have preached for nearly a century: Keep models in a ...