Protein regulator of sugars and fats may work with an unexpected partner—itself

A protein that is a key modulator of fat, glucose and cholesterol levels in the body usually works in tandem with another ...

Mitochondria can reshape lipid storage in cells by repurposing a protein-insertion complex

A recent study by the University of Bonn and University Hospital Bonn and the University of Freiburg shows that the ...
Nature

Mitochondrial Complex I and Respiratory Chain Function

Mitochondrial Complex I (NADH:ubiquinone oxidoreductase) is the largest enzyme complex of the respiratory chain, essential for cellular energy production. This multiprotein assembly couples the ...

Lab-in-the-loop framework enables rapid evolution of complex multi-mutant proteins

The search space for protein engineering grows exponentially with complexity. A protein of just 100 amino acids has 20100 possible variants—more combinations than atoms in the observable universe.
EurekAlert!

New model enables the study of how protein complex influences mitochondrial function

A study by the Center for Redox Processes in Biomedicine (Redoxoma) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil) presents a valuable new experimental model for investigating ...
BioTechniques

Cryo-EM reveals new aspects of CRISPR-Cas biology

Researchers at Vilnius University (Lithuania) have uncovered how the bacterial protein Cas9, better known as the CRISPR-Cas ...