Scientists capture early stages of immune response inside cells

In new research, scientists at the Department of Energy's SLAC National Accelerator Laboratory, in collaboration with ...
EurekAlert!

New biomarker for immunoglobulin a nephropathy identified

Immunoglobulin A (IgA) nephropathy results from the accumulation of IgA-containing immune complexes (IgA-ICs) and aberrant ...
The American Journal of Managed Care

Pathogenesis of IgA Nephropathy: The 4-Hit Cascade, A Proliferation-Inducing Ligand (APRIL), and cytokines

Panelists discuss how immunoglobulin A (IgA) nephropathy develops through a complex 4-hit cascade involving aberrant IgA1 glycosylation, anti-glycan antibody formation, immune complex deposition, and ...
The American Journal of Managed Care

Current Treatments for IgA Nephropathy and the 4-Hit Cascade

Panelists discuss how current immunoglobulin A (IgA) nephropathy treatments primarily target downstream inflammatory pathways of the 4-hit cascade, with emerging therapies now beginning to address ...