Dynamic switching between revival stem cells and conventional intestinal stem cells enables efficient tissue repair without ...

Drosophila melanogaster has long served as a powerful model for dissecting the principles of tissue homeostasis and regeneration. Within the adult midgut, intestinal stem cells (ISCs) perform the ...

A new study led by Hartmut Geiger at the University of Ulm, Germany and Yi Zheng and Kodandaramireddy Nalapareddy, CCHMC, Cincinnati, USA reveals that age-related changes in the gut microbiota ...

Cedars-Sinai Health Sciences University investigators have for the first time created human intestinal organoids that include ...

Image Caption: The signaling pathways involved in the intestinal stem cell niche and cell fate determination. Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and ...

An international study led by Paolo Fiorina from Boston Children's Hospital and in collaboration with researchers from the University of Milan highlights the beneficial effect of inhibiting the death ...

The interplay between the circadian clock, intestinal stem cell niche, and epithelial cell fate is shaping our understanding of how gut homeostasis and cellular regeneration are regulated. Recent ...

A new study reported in Nature has determined that the amino acid cysteine could promote regeneration among cells in the small intestine. The work showed that cysteine can activate an immune signaling ...

Chronic inflammation in the gut does more than cause pain and discomfort for people with inflammatory bowel disease. A ...

Conventional studies on stem cell fates are primarily focused on transcription factors, with the limited consideration for 3D genome architecture. The cohesin complex dynamically restructures ...

The terms "intestinal barrier" and "intestinal permeability" describe two different aspects of the same anatomical structure, the intestinal wall composed of four layers, the mucosa, the submucosa, ...