The sequence specificity and programmability of DNA binding and cleavage have enabled widespread applications of CRISPR-Cas12a in genetic engineering. As an RNA-guided CRISPR endonuclease, Cas12a ...
Genome-wide chromosome conformation capture methods (such as Hi-C 1) revealed that mammalian genomes are folded into thousands of topologically associating domains (TADs) spanning 100–1,500 kb 2,3,4,5 ...
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