Mitotic segregation of chromosomes depends on correct assembly of the bipolar spindle and mitosis is delayed by the spindle assembly checkpoint (SAC). In the July 19 Nature, Gachet et al., at the ...
Recent evidence has suggested threonine tyrosine kinase (TTK) as a crucial element of the mitotic checkpoint for the correct functioning of spindle assembly checkpoint (SAC), making it a potential ...
An open-label, phase II study of tipifarnib for the treatment of HRAS mutant solid tumors, including squamous cell carcinomas of the head and neck. Background: TTK (MPS1), a dual-specificity ...
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