I think it would depend on the motherboard. Some can make a USB drive appear as an INT 13 device, and I've seen some USB drivers for DOS.

Running Windows completely off of a USB flash drive is quite handy if you want to try a newer or older version of Windows without affecting your current system. The USB drive can also serve as a ...

For a long time, Microsoft didn’t sell Windows install media in the form of bootable USB flash drives. Instead, it prefered to stick to old-school DVD media, despite the fact that many notebooks today ...

I have an IDE laptop drive with Windows 98 installed. I also have a USB to IDE adapter. I've tried plugging the drive into a couple Windows machines, and the disk shows in Disk Manager, but it is ...