Joao Pedro's hat-trick breathes fresh life into Chelsea's Champions League charge with a statement win at rivals Aston Villa.
Substitute William Osula scores a superb late winner as 10-man Newcastle United inflict Michael Carrick's first defeat as Manchester United manager.
Title-chasing Manchester City stumble at home by being held to draw by relegation-threatened Nottingham Forest to fall seven points adrift of Premier League leaders Arsenal.
Ipswich Town climb into third place in the Championship by beating promotion hopefuls Hull City at Portman Road.